Small oxoacids of sulfur (SOS) are elusive molecules like sulfenic acid, HSOH, and sulfinic acid, HS(O)OH, generated during the oxidation of hydrogen sulfide, H2S, in aqueous solution. Unlike their alkyl homologs, there is a little data on their generation and speciation during H2S oxidation. These SOS may exhibit both nucleophilic and electrophilic reactivity, which we attribute to interconversion between S(II) and S(IV) tautomers. We find that SOS may be trapped in situ by derivatization with nucleophilic and electrophilic trapping agents and then characterized by high resolution LC MS. In this report, we compare SOS formation from H2S oxidation by a variety of biologically relevant oxidants. These SOS appear relatively long lived in aqueous solution, and thus may be involved in the observed physiological effects of H2S.

译文

:硫的少量含氧酸(SOS)是难以捉摸的分子,例如亚硫酸,HSOH和亚硫酸HS(O)OH,它们是在水溶液中硫化氢H2S氧化过程中产生的。与它们的烷基同系物不同,关于硫化氢氧化过程中它们的生成和形态的数据很少。这些SOS可能同时表现出亲核和亲电反应性,我们将其归因于S(II)和S(IV)互变异构体之间的相互转化。我们发现SOS可以通过亲核和亲电捕集剂衍生化而被原位捕集,然后以高分辨率LC MS为特征。在本报告中,我们比较了各种生物学上相关的氧化剂从H2S氧化形成SOS的过程。这些SOS在水溶液中的寿命相对较长,因此可能与所观察到的H2S的生理效应有关。

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