The present study was conducted to clarify the mechanism of toxicity of organic compounds using lipid model membranes (liposomes and planar lipid membranes). The compounds studied were trialkyltin and trialkyllead chlorides, dialkyltin dichlorides and some inorganic forms of those metals. Two different (anionic and cationic) detergents were also used in the experiments to change the surface properties of liposomes. As a measure of interaction between the compounds studied and model membranes were the release of liposome bound praseodymium and the change in stability of planar membranes under the influence of those compounds. On the basis of the results obtained it was postulated that the mechanism of interaction between tin- and leadorganics and model lipid membranes is a combination of different factors featuring interacting sides. The most important properties determining the behaviour of organic compounds in the interaction were lipophilicity and polarity of different parts of the organics and the steric arrangement they can take in the medium. On the other hand, the surface potential of the lipid bilayer and the environment of the lipid molecules, that play a significant role in the availability of the lipid bilayer to the organics, were important factors in the interaction.

译文

进行本研究以阐明使用脂质模型膜(脂质体和平面脂质膜)的有机化合物的毒性机理。所研究的化合物为三烷基锡和三烷基氯化铅,二烷基二氯化锡和这些金属的某些无机形式。实验中还使用了两种不同的(阴离子和阳离子)去污剂来改变脂质体的表面性质。脂质体结合的ody的释放以及在这些化合物的影响下平面膜稳定性的变化是衡量所研究化合物与模型膜之间相互作用的一种量度。根据获得的结果,假设锡和铅有机物与模型脂质膜之间的相互作用机理是具有相互作用侧的不同因素的组合。决定有机化合物在相互作用中的行为的最重要特性是亲脂性和有机物不同部分的极性以及它们在介质中可采取的空间排列。另一方面,脂质双层的表面电势和脂质分子的环境在脂质双层对有机物的利用中起着重要作用,是相互作用的重要因素。

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