The hepatitis C virus (HCV) infects 3% of the world's population, or approximately 170 million people. Most of those acutely infected progress to chronic infection and are unresponsive to existing antiviral treatment. Over a 20-year period, chronic HCV infection leads to cirrhosis and the sequelae of end-stage liver disease, including hepatic encephalopathy, ascites, variceal haemorrhage and hepatocellular carcinoma. Orthotopic liver transplantation (OLT) is the optimal treatment for decompensated HCV cirrhosis, but is limited by organ availability and universal graft reinfection. This review discusses the results with OLT for HCV from the Dumont-UCLA Liver Transplant Center and discusses future directions in the management of HCV.

译文

:丙型肝炎病毒(HCV)感染了全球3%的人口,约有1.7亿人。大多数急性感染者会发展为慢性感染,并且对现有的抗病毒治疗无反应。在20年的时间里,慢性HCV感染会导致肝硬化和终末期肝病的后遗症,包括肝性脑病,腹水,静脉曲张出血和肝细胞癌。原位肝移植(OLT)是失代偿性HCV肝硬化的最佳治疗方法,但受到器官可用性和通用移植物再感染的限制。这篇综述讨论了来自杜蒙特-UCLA肝移植中心的OLT HCV检测结果,并讨论了HCV管理的未来方向。

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