Infused CD34 cell count has a significant impact on transplant outcome. In this retrospective study, we aimed to analyze the impact of donor iron parameters on peripheral blood stem cell (PBSC) collection. A total of 303 related donors were included in the study. The mobilization regimen, recombinant G-CSF, was given for four consecutive days. A CD34+ cell count below 2×106/kg was defined as mobilization failure which was demonstrated in 23 donors (7.6%). Mobilization failure was more frequent in female donors than male donors (13.7% vs 3.4%). Body mass index, mean corpuscular volume, hemoglobin and ferritin levels were found to be lower in donors with mobilization failure. Body mass index was significantly correlated with PBSC count on the 4th day of G-CSF. Body mass index, male gender, mean corpuscular volume and ferritin levels had significant impact on PBSC count. Although PBSC count was found to be similar between female and male donors, female gender was shown to have an adverse impact on PBSC collection, which may be attributed to lower body weight and concurrent iron deficiency.

译文

:注入的CD34细胞数量对移植结果有重要影响。在这项回顾性研究中,我们旨在分析供体铁参数对外周血干细胞(PBSC)收集的影响。总共303名相关捐助者被纳入研究。连续四天给予了动员方案,即重组G-CSF。低于2×106 / kg的CD34细胞计数被定义为动员失败,这在23个捐献者(7.6%)中得到证实。女性捐赠者的动员失败率比男性捐赠者更高(13.7%vs 3.4%)。发现动员失败的献血者的体重指数,平均红细胞体积,血红蛋白和铁蛋白水平较低。体重指数与G-CSF第4天的PBSC计数显着相关。体重指数,男性,平均红细胞体积和铁蛋白水平对PBSC计数有显着影响。尽管发现雌性和雄性供体之间的PBSC计数相似,但显示出性别对PBSC收集有不利影响,这可能归因于体重减轻和同时发生的铁缺乏症。

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