Male breast cancer (MBC) is an uncommon neoplasm that shares several biologic characteristics with its female counterpart. In the latter, abnormalities in the expression and/or copy number of the ERBB2 gene are present in 10% to 30% of invasive carcinoma and behave as poor prognostic markers. ERBB2 abnormalities have also been reported in MBC, yet at lower frequency, but their prognostic significance remains controversial. Furthermore, no study has addressed the impact of chromosome 17 abnormalities in MBC survival. In this study, the ERBB2-gene status (overexpression and amplification) and chromosome 17 numerical abnormalities were investigated in a series of 50 archival cases of MBC. The results, together with patient's age, histologic grade, pathologic stage, and estrogen receptor status were correlated with overall survival. ERBB2-protein overexpression was present in 7 cases (14%), ERBB2-gene amplification in 4 (8%), and aneuploidy of chromosome 17 in 12 cases (33.3%). The pathologic stage, ERBB2 overexpression and ERBB2 amplification were significantly correlated with overall survival (P=0.002, 0.016, and 0.009, respectively). No correlation was observed between chromosome 17 aneuploidy and overall survival. Therefore, despite their low incidence in MBC, expression abnormalities of ERBB2 behave, together with the pathologic stage of the tumor, as predictors of overall survival, akin to what has been reported for its female counterpart.

译文

:男性乳腺癌(MBC)是一种罕见的肿瘤,与女性乳腺癌具有某些生物学特性。在后者中,ERBB2基因表达和/或拷贝数异常存在于10%至30%的浸润性癌中,并表现为不良的预后指标。在MBC中也有ERBB2异常的报道,但频率较低,但其预后意义仍存在争议。此外,还没有研究解决17号染色​​体异常对MBC存活的影响。在这项研究中,对一系列50例MBC存档病例中的ERBB2基因状态(过表达和扩增)和17号染色​​体数字异常进行了研究。结果,以及患者的年龄,组织学等级,病理分期和雌激素受体状态与总体生存率相关。 ERBB2蛋白过表达7例(14%),ERBB2基因扩增4例(8%),染色体17的非整倍性12例(33.3%)。病理阶段,ERBB2过表达和ERBB2扩增与总生存率显着相关(分别为P = 0.002、0.016和0.009)。在第17号染色​​体非整倍性与总体存活率之间未发现相关性。因此,尽管其在MBC中的发病率较低,但ERBB2的表达异常以及肿瘤的病理阶段仍可作为总体存活率的预测指标,类似于其女性对应物的报道。

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