The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to proliferate, however, proliferation declines in the course of migration to the olfactory bulb. While migrating in the RMS, neuroblasts receive a plethora of stimuli that modify transcription according to the local microenvironment, and eventually modulate neuroblast migration. In the target area, the olfactory bulb, neuroblasts develop into mature neurons. In this review, we discuss dynamic changes of the transcriptome that occur during the "lifetime" of a neuroblast, thereby governing the activation or inhibition of distinct genes/pathways that are responsible for proliferation, migration and differentiation.

译文

侧脑室下区 (SVZ) 是产后哺乳动物大脑中的主要神经源性区域。在动物的一生中,每天都会产生成千上万的神经母细胞。新生的神经母细胞通过鼻状迁移流 (RMS) 迁移到嗅球中,在那里它们成熟为不同的神经元亚型。离开SVZ的神经母细胞保留了增殖的能力,但是,在迁移到嗅球的过程中,增殖下降。在RMS中迁移时,神经母细胞会接受大量刺激,这些刺激会根据局部微环境改变转录,并最终调节神经母细胞的迁移。在靶区,嗅球、神经母细胞发育成成熟的神经元。在这篇综述中,我们讨论了在神经母细胞的 “寿命” 期间发生的转录组的动态变化,从而控制了负责增殖,迁移和分化的不同基因/途径的激活或抑制。

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