Recently, an elevation in skin cholesterol level has been implicated in skin inflammation. Given the potential therapeutic effects of soy on low grade inflammatory diseases, we hypothesized that a CHOL diet could promote an inflammatory response in skin and that soy milk (SM) or fermented soy milk (F.SM) could prevent this cholesterol-induced skin inflammation. To test this hypothesis, freeze-dried SM or F.SM was provided as a protein replacement for 20% of the casein in the diets of Sprague-Dawley (SD) rats. The animals were divided into the following groups: (1) control group (CTRL), AIN76A diet without cholesterol, (2) high cholesterol (CHOL) group, AIN76A with 1% (w/w) cholesterol, (3) SM group, CHOL diet with freeze-dried SM, and (4) F.SM group, CHOL diet with F.SM. In the CHOL group, the expression levels of pro-inflammatory genes, including IL-1β, IL-1α, iNOS, and COX-2, were elevated. In comparison, the SM and F.SM groups displayed the lowered expression of IL-1β, COX-2, F4/80, and Cd68, an increase of a n-3/n-6 ratio, and a reduction in the estimated desaturase activities of delta 5 desaturase (D5D) and steaoryl CoA desaturase (SCD-1). In particular, F.SM significantly increased the proportion of dihomo-γ-linolenic acid (DGLA) in skin fatty acid (FA) composition compared with the CHOL group. Here we present evidence that SM or F.SM could alleviate the inflammatory response in the skin that is triggered by excess dietary cholesterol by reducing the expression of pro-inflammatory genes. This response could be partly associated with a decreased in macrophages in skin and/or by modulation of the skin's FA composition.

译文

最近,皮肤胆固醇水平的升高与皮肤炎症有关。鉴于大豆对低度炎症性疾病的潜在治疗作用,我们假设CHOL饮食可以促进皮肤的炎症反应,并且豆浆 (SM) 或发酵豆浆 (F.SM) 可以预防这种胆固醇引起的皮肤炎症。为了检验这一假设,提供了冻干SM或F.SM作为蛋白质替代物,用于在Sprague-Dawley (SD) 大鼠的饮食中20% 酪蛋白。将动物分为以下组 :( 1) 对照组 (CTRL),AIN76A饮食无胆固醇,(2) 高胆固醇 (CHOL) 组,AIN76A 1% (w/w) 胆固醇,(3) SM组,CHOL饮食加冻干SM,和 (4) F.SM组,CHOL饮食与F.SM。在CHOL组中,促炎基因 (包括IL-1β,IL-1α,iNOS和COX-2) 的表达水平升高。相比之下,SM和F.SM组显示出IL-1β,COX-2,F4/80和Cd68的表达降低,n-3/n-6比增加以及delta 5的估计去饱和酶活性降低。去饱和酶 (D5D) 和steaoryl CoA去饱和酶 (SCD-1)。特别是,与CHOL组相比,F.SM显着增加了皮肤脂肪酸 (FA) 组成中二高-γ-亚麻酸 (DGLA) 的比例。在这里,我们提供了证据,表明SM或F。SM可以通过减少促炎基因的表达来减轻由过量饮食胆固醇引发的皮肤炎症反应。这种反应可能部分与皮肤中巨噬细胞的减少和/或通过调节皮肤的FA组成有关。

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