There is growing preclinical evidence for the involvement of glutamate in the behavioral actions of nicotine. The aim of this study, was to investigate the role of N-methyl-D-aspartate (NMDA) receptors in the cognitive and subjective effects of smoking in humans. Sixty regular smokers took part in this double-blind placebo controlled study, that investigated the effect of the NMDA-antagonist memantine (40 mg) and the nicotinic-receptor antagonist mecamylamine (10 mg) on smoking-induced improvement in performance of a task of sustained attention and on smoking-induced changes in subjective effects and craving. Increases in subjective ratings of 'buzzed' following smoking were reversed by memantine, but not by mecamylamine. In contrast, improvement on a Rapid Visual Information Processing task by smoking was opposed by mecamylamine, but not by memantine. Smoking reduced craving for cigarettes, but neither drug altered this effect. Our results suggest that glutamatergic mechanisms may have differential involvement in the subjective and cognitive actions of smoking. Further investigations using different ligands are warranted to fully characterize the role of glutamate underlying the consequences of smoking behavior.

译文

:越来越多的临床前证据表明谷氨酸参与尼古丁的行为活动。这项研究的目的是调查N-甲基-D-天冬氨酸(NMDA)受体在吸烟对人类的认知和主观影响中的作用。 60名常规吸烟者参加了这项双盲安慰剂对照研究,该研究调查了NMDA拮抗剂美金刚(40 mg)和烟碱样受体拮抗剂美卡明胺(10 mg)对吸烟引起的一项任务的改善的作用。持续关注和吸烟引起的主观效果和渴望的变化。美金刚可以逆转吸烟后“嗡嗡”的主观评分,但美卡敏不能逆转。相比之下,美卡明胺反对吸烟改善快速视觉信息处理任务,而美金刚胺则反对。吸烟减少了对香烟的渴望,但是没有一种药物改变了这种效果。我们的结果表明,谷氨酸能机制可能在吸烟的主观和认知行为中有不同的参与。有必要使用不同的配体进行进一步研究,以充分表征谷氨酸在吸烟行为后果中的作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录