Extensive literatures have shown significant trend of progressive electrical changes according to the proliferative characteristics of breast epithelial cells. Physiologists also further postulated that malignant transformation resulted from sustained depolarization and a failure of the cell to repolarize after cell division, making the area where cancer develops relatively depolarized when compared to their non-dividing or resting counterparts. In this paper, we present a new approach, the Biofield Diagnostic System (BDS), which might have the potential to augment the process of diagnosing breast cancer. This technique was based on the efficacy of analysing skin surface electrical potentials for the differential diagnosis of breast abnormalities. We developed a female breast model, which was close to the actual, by considering the breast as a hemisphere in supine condition with various layers of unequal thickness. Isotropic homogeneous conductivity was assigned to each of these compartments and the volume conductor problem was solved using finite element method to determine the potential distribution developed due to a dipole source. Furthermore, four important parameters were identified and analysis of variance (ANOVA, Yates' method) was performed using design (n = number of parameters, 4). The effect and importance of these parameters were analysed. The Taguchi method was further used to optimise the parameters in order to ensure that the signal from the tumour is maximum as compared to the noise from other factors. The Taguchi method used proved that probes' source strength, tumour size and location of tumours have great effect on the surface potential field. For best results on the breast surface, while having the biggest possible tumour size, low amplitudes of current should be applied nearest to the breast surface.

译文

根据乳腺上皮细胞的增殖特性,大量文献显示出明显的进行性电变化趋势。生理学家还进一步推测,恶性转化是由持续的去极化和细胞分裂后细胞无法重新极化引起的,与未分裂或静息的对应物相比,癌症发展的区域相对去极化。在本文中,我们提出了一种新方法,即生物场诊断系统 (BDS),该方法可能具有增强乳腺癌诊断过程的潜力。该技术基于分析皮肤表面电势以鉴别诊断疾病乳房异常的功效。我们通过将乳房视为仰卧状态下的半球,具有不同厚度的各层,从而开发了一种接近实际的女性乳房模型。将各向同性均匀电导率分配给每个隔室,并使用有限元方法解决体积导体问题,以确定由于偶极源而产生的电势分布。此外,确定了四个重要参数,并使用设计 (n = 参数数,4) 进行了方差分析 (ANOVA,yates方法)。分析了这些参数的影响和重要性。Taguchi方法进一步用于优化参数,以确保与来自其他因素的噪声相比,来自肿瘤的信号最大。使用Taguchi方法证明,探针的来源强度,肿瘤大小和肿瘤位置对表面电势场有很大影响。为了在乳房表面获得最佳效果,同时具有最大可能的肿瘤大小,应在最接近乳房表面的位置施加低振幅的电流。

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