Results of a study on the relative frequencies of tumors in American black and Nigerian children were compared with data from the Childhood Cancer Registries in Manchester, United Kingdom, and Kampala, Uganda. The American black child living in Washington, D.C. and the Caucasian child living in Manchester had similar high frequencies for leukemia and glioma, whereas the incidence of lymphoma and retinoblastoma was low. African children living in Nigeria or Uganda had the opposite frequency patterns. These differences in frequencies of tumors between two ethnologically related population groups, American black and Nigerian, suggested the influence of environmental factors in the etiology of these tumors, even though exposure to environmental carcinogens was short. The rarity of Ewing's sarcoma and testicular tumors in American black and Nigerian children suggested a genetic influence.

译文

将美国黑人和尼日利亚儿童肿瘤相对频率的研究结果与英国曼彻斯特和乌干达坎帕拉的儿童癌症登记处的数据进行了比较。居住在华盛顿特区的美国黑人儿童和居住在曼彻斯特的高加索儿童患白血病和神经胶质瘤的频率相似,而淋巴瘤和视网膜母细胞瘤的发生率较低。生活在尼日利亚或乌干达的非洲儿童的频率模式相反。尽管暴露于环境致癌物的时间很短,但两个与种族相关的人群 (美国黑人和尼日利亚人) 之间的肿瘤频率差异表明环境因素对这些肿瘤的病因的影响。美国黑人和尼日利亚儿童尤因肉瘤和睾丸肿瘤的稀有性表明了遗传影响。

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