METHOD:They studied 33 inpatients with major depression, melancholic type, all of whom responded positively to total sleep deprivation. Twelve of the patients were men and 21 were women; their mean age was 46.7 years (SD = 13.7). After total sleep deprivation, the patients started a sleep schedule from 5:00 p.m. to 12:00 midnight, which then was shifted back by 1 hour each day until a sleep time of 11:00 p.m. to 6:00 a.m. was reached.

RESULTS:Twenty (61%) of the 33 patients who responded to total sleep deprivation with an improved state of mood maintained this improvement during sleep phase advance therapy. Drug-free and medicated patients did not differ from each other.

CONCLUSIONS:The rapid amelioration of mood observed with total sleep deprivation can be preserved with a succeeding phase shift of the sleep period.

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OBJECTIVE:The authors' goal was to test the hypothesis that the antidepressant effect of total sleep deprivation can be maintained by initially avoiding sleep during a supposedly "critical" time period in the early morning.

METHOD:They studied 33 inpatients with major depression, melancholic type, all of whom responded positively to total sleep deprivation. Twelve of the patients were men and 21 were women; their mean age was 46.7 years (SD = 13.7). After total sleep deprivation, the patients started a sleep schedule from 5:00 p.m. to 12:00 midnight, which then was shifted back by 1 hour each day until a sleep time of 11:00 p.m. to 6:00 a.m. was reached.

RESULTS:Twenty (61%) of the 33 patients who responded to total sleep deprivation with an improved state of mood maintained this improvement during sleep phase advance therapy. Drug-free and medicated patients did not differ from each other.

CONCLUSIONS:The rapid amelioration of mood observed with total sleep deprivation can be preserved with a succeeding phase shift of the sleep period.

译文

目的:作者的目标是检验以下假设:通过在清晨所谓的“关键”时间段内最初避免入睡,可以维持完全睡眠剥夺的抗抑郁作用。
< br> METHOD :他们研究了33例重度抑郁,忧郁型抑郁症住院患者,所有患者对总睡眠不足的反应都积极。病人中有十二名是男性,二十一名是女性;他们的平均年龄为46.7岁(SD = 13.7)。在完全睡眠剥夺之后,患者从下午5:00开始睡眠计划。到午夜12:00,然后每天回移1小时,直到晚上11:00的睡眠时间。

结果:在对总睡眠剥夺有改善的情绪状态的33例患者中,有20例(61%)在睡眠阶段保持了这种改善提前治疗。无药和药物治疗的患者没有区别。

结论:随着睡眠时间的相移,可以保持完全睡眠剥夺所观察到的情绪快速改善。 。

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