BACKGROUND:The hormone melatonin plays a key role in the proper functioning of the circadian timing system (CTS). Exogenous melatonin has been shown to be beneficial in cases of CTS dysfunction and sleep disturbances. The aim of our study was to relate 24-h melatonin excretion to objective sleep measures. METHODS:A total of 67 individuals were included in the study: 29 healthy subjects (16 women, 13 men; mean age 62.4 y, range 24-86) and 38 outpatients with neuropsychiatric sleep-related disturbances (25 women, 13 men; mean age 46.5 y, range 21-69). Over two consecutive nights in the sleep laboratory, polysomnographic (PSG) recordings were made and urine samples were collected at predefined intervals. RESULTS:Our data failed to show any age-controlled partial correlation between 6-sulphatoxymelatonin (aMT6s) parameters and PSG parameters in either of the two groups. CONCLUSION:Measuring endogenous melatonin does not seem to be an adequate way to evaluate sleep quality. This could be due to the fact that the size of the pineal gland and the amount of melatonin produced vary 20-fold between individuals.

译文

背景:褪黑激素在昼夜节律计时系统(CTS)的正常运转中起着关键作用。外源性褪黑素已被证明对CTS功能障碍和睡眠障碍有益。我们研究的目的是将24小时褪黑激素排泄与客观睡眠指标联系起来。
方法:研究共纳入67位个体:29位健康受试者(16位女性,13位男性;平均年龄62.4岁,范围24-86)和38位神经精神病患者与睡眠相关的门诊患者(25位女性,13位男性;平均年龄46.5岁,范围21-69)。在睡眠实验室连续两个晚上,进行了多导睡眠图(PSG)记录,并以预定的时间间隔收集了尿液样本。
结果:我们的数据未能显示两组中的6-硫代氧黑素(aMT6s)参数和PSG参数之间存在任何年龄控制的部分相关性。
结论:测量内源性褪黑激素似乎并不是评估睡眠质量的适当方法。这可能是由于松果体的大小和褪黑激素的产生量在个体之间变化了20倍。

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