Populations with two sexes are vulnerable to a pair of genetic conflicts: sexual antagonism that can arise when alleles have opposing fitness effects on females and males; and parental antagonism that arises when alleles have opposing fitness effects when maternally and paternally inherited. This paper extends previous theoretical work that found stable linkage disequilibrium (LD) between sexually antagonistic loci. We find that LD is also generated between parentally antagonistic loci, and between sexually and parentally antagonistic loci, without any requirement of epistasis. We contend that the LD in these models arises from the admixture of gene pools subject to different selective histories. We also find that polymorphism maintained by parental antagonism at one locus expands the opportunity for polymorphism at a linked locus experiencing parental or sexual antagonism. Taken together, our results predict the chromosomal clustering of loci that segregate for sexually and parentally antagonistic alleles. Thus, genetic conflict may play a role in the evolution of genomic architecture.

译文

:有两个性别的人容易受到一对遗传冲突的影响:等位基因对雌性和雄性有相反的适应作用时,可能会产生性拮抗作用;当等位基因在母本和父本遗传时具​​有相反的适应性效应时,就会产生父母对立。本文扩展了先前的理论工作,该工作发现了性拮抗基因座之间存在稳定的连锁不平衡(LD)。我们发现在亲本拮抗基因座之间,性与亲本拮抗基因座之间也产生LD,而无需上位。我们认为这些模型中的LD来源于受不同选择历史影响的基因库的混合。我们还发现,在一个基因座处由父母拮抗作用维持的多态性扩大了在经历父母或性拮抗作用的连锁基因座处多态性的机会。综上所述,我们的结果预测了针对性和亲代拮抗等位基因分离的基因座的染色体簇。因此,遗传冲突可能在基因组结构的进化中起作用。

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