Thirty-five patients with definite multiple sclerosis (MS) were studied. They underwent neuropsychological testing and magnetic resonance imaging (MRI). The MRI findings at different brain areas levels were compared with the neuropsychological findings. A quantitative system was used to measure MRI-MS lesions. In this series, a positive correlation was established between memory and learning disturbances measured by Battery 144, and the lesions measured by MRI (total, hemispheric and, particularly, periventricular lesions). MRI can detect MS lesions, and this study shows that a correlation between MRI and neuropsychological findings is possible if quantitative methods are used to distinguish different MS involvement areas in relation to neuropsychological tasks. These findings suggest that hemispheric lesions in MS produce cognitive disturbances and MRI could be a useful tool in predicting memory and learning impairment.

译文

:研究了35例明确的多发性硬化症(MS)患者。他们接受了神经心理学测试和磁共振成像(MRI)。将不同大脑区域水平的MRI检查结果与神经心理学检查结果进行比较。定量系统用于测量MRI-MS病变。在这个系列中,通过电池144测量的记忆和学习障碍与通过MRI测量的病变(总的,半球的,尤其是脑室周围的病变)之间建立了正相关。 MRI可以检测MS病变,这项研究表明,如果使用定量方法区分与神经心理学任务相关的不同MS累及区域,则MRI与神经心理学发现之间可能存在关联。这些发现表明,MS的半球病变会产生认知障碍,而MRI可能是预测记忆和学习障碍的有用工具。

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