Dermatophagoides farinae-, ovalbumin- and lactalbumin-specific IgG, IgG1, IgG4, IgA and IgM were evaluated in 161 healthy children [Group 1], 84 children with bronchial asthma and/or allergic rhinitis but without atopic dermatitis [Group 2], and 54 children with atopic dermatitis but without bronchial asthma and allergic rhinitis [Group 3]. We also studied D. farinae-, egg-white-, and milk-specific IgE of children with allergic diseases. D. farinae-specific IgG, IgG1, IgG4 and IgA in Groups 2 and 3 increased until 5 years of age and thereafter they remained constant. After 2 years of age, D. farinae-specific IgG, IgG1, IgG4 and IgA in Group 2 were higher than those in Groups 1 and 3. Ovalbumin- and lactalbumin-specific IgG, IgG1, IgG4 and IgA in Groups 2 and 3 increased until 1 year of age and thereafter decreased. Until 1 year of age, ovalbumin- and lactalbumin-specific IgG, IgG1 and IgG4 in Groups 3 were higher than those in Groups 1 and 2. D. farinae-, ovalbumin- and lactalbumin-specific IgM were constant in all ages of all groups. These results suggest that atopic dermatitis in young children is related to food-specific immunoglobulins and that respiratory allergic diseases in older children is related to D. farinae-specific immunoglobulins.

译文

:在161名健康儿童(第1组),84例支气管哮喘和/或过敏性鼻炎但无特应性皮炎的儿童(第2组)中评估了粉状皮癣,卵白蛋白和乳白蛋白特异性IgG,IgG1,IgG4,IgA和IgM。 54例患特应性皮炎但无支气管哮喘和过敏性鼻炎的儿童[3组]。我们还研究了患有过敏性疾病的儿童的D. farinae,蛋清和牛奶特异性IgE。第2组和第3组中的D. farinae特异性IgG,IgG1,IgG4和IgA升高至5岁,此后保持恒定。 2岁后,第2组的粉虱D. farinae特异性IgG,IgG1,IgG4和IgA高于第1和3组。第2和第3组的卵白蛋白和乳白蛋白特异性IgG,IgG1,IgG4和IgA增加。直到1岁,此后有所减少。直到1岁之前,第3组中卵白蛋白和乳白蛋白特异性IgG,IgG1和IgG4高于第1组和第2组。粉虱,卵白蛋白和乳白蛋白特异性IgM在所有组的所有年龄中均保持不变。 。这些结果表明,幼儿的特应性皮炎与食物特异性免疫球蛋白有关,而年龄较大的儿童的呼吸道过敏性疾病与D. farinae特异性免疫球蛋白有关。

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