M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and their association with clinical characteristics need to be further evaluated.A total of 136 patients were involved as inception group because serum anti-PLA2R antibody and glomerular PLA2R antigen were simultaneously measured. We examined serum anti-PLA2R antibody by ELISA and glomerular PLA2R deposition by immunofluorescence assay.Positive serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8% (80/136) and 95.6% (130/136) patients, respectively (P < .001). Proteinuria, serum total protein, serum albumin, serum creatinine, and estimated glomerular filtration rate (eGFR) had significant differences between patients with serum anti-PLA2R antibody and those without. Serum anti-PLA2R antibody levels were correlated with serum albumin, serum creatinine, eGFR, and proteinuria. Glomerular PLA2R deposition intensities were weakly correlated with proteinuria. Unexpectedly, there was a positive correlation rather than a negative correlation between glomerular PLA2R deposition intensity and eGFR.In conclusion, serum anti-PLA2R antibody is more closely correlated with disease activity and renal function than glomerular PLA2R deposition.

译文

:M型磷脂酶A2受体(PLA2R)是原发性膜性肾病(PMN)的主要靶抗原。先前的研究已经评估了血清抗PLA2R抗体的诊断价值。然而,血清抗PLA2R抗体与肾小球PLA2R沉积的相关性及其与临床特征的相关性需要进一步评估。由于同时检测了血清抗PLA2R抗体和肾小球PLA2R抗原,因此共有136例患者入组。 。我们通过ELISA检测了血清抗PLA2R抗体,并通过免疫荧光法检测了肾小球PLA2R沉积。分别在58.8%(80/136)和95.6%(130/136)患者中观察到阳性血清抗PLA2R抗体和肾小球PLA2R沉积(P <.001)。蛋白尿,血清总蛋白,血清白蛋白,血清肌酐和估计的肾小球滤过率(eGFR)在有血清抗PLA2R抗体的患者和没有血清抗PLA2R抗体的患者之间有显着差异。血清抗PLA2R抗体水平与血清​​白蛋白,血清肌酐,eGFR和蛋白尿相关。肾小球PLA2R沉积强度与蛋白尿弱相关。出乎意料的是,肾小球PLA2R沉积强度与eGFR之间呈正相关而非负相关。总之,血清抗PLA2R抗体与肾小球PLA2R沉积与疾病活动性和肾功能之间的相关性更高。

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