Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Our retrospective study was performed from June 2014 to April 2015. Oocyte donors were recruited and stimulated under the antagonist protocol with gonadotrophin-releasing hormone (GnRH) agonist to trigger ovulation. In 851 stimulation cycles, we determined the association among serum total and bioavailable vitamin D levels, ovarian reserve and response to ovarian stimulation and the reproductive outcome in their recipients. We showed that vitamin D levels were unrelated to ovarian reserve or ovarian response after ovarian stimulation; in oocyte recipients, gestational outcome did not differ according to a donor's vitamin D serum status. No correlation was observed between serum AMH and vitamin D. Bioavailable vitamin D was not related to recipients' ongoing pregnancy rate. Highly prevalent vitamin D insufficiency neither impaired ovarian reserve nor response or oocyte quality in egg donors. No evidence was found for recommending the analysis of vitamin D status in oocyte donors.

译文

:最近,发现维生素D的人群中维生素D含量低的发现已引起人们对维生素D的日益增长的兴趣。同样,人们已经对抗苗勒氏管激素(AMH)在生殖生理中的作用表现出了极大的兴趣。关于维生素D状态是否与卵巢功能有关的大量混淆可以在文献中找到。我们的回顾性研究于2014年6月至2015年4月进行。在促性腺激素释放激素(GnRH)激动剂的拮抗方案下,募集卵母细胞供体并对其进行刺激以触发排卵。在851个刺激周期中,我们确定了血清总维生素D和生物有效性维生素D水平,卵巢储备以及对卵巢刺激的反应以及其受体的生殖结局之间的关联。我们发现维生素D水平与卵巢刺激后的卵巢储备或卵巢反应无关。在卵母细胞受体中,妊娠结果根据供体的维生素D血清状态而不同。血清AMH与维生素D之间没有相关性。可利用的维生素D与接受者的持续妊娠率无关。高度普遍的维生素D缺乏症既不损害卵子捐献者的卵巢储备,也不损害其反应或卵母细胞质量。没有证据表明建议对卵母细胞供体中的维生素D状况进行分析。

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