BACKGROUND:To investigate the relationship between the levels of serum complement C1q and the risk and severity of acute ischemic stroke, a total of 154 patients with acute ischemic stroke and 42 healthy volunteers as normal controls were enrolled in the present study. METHODS:According to the onset time of stroke, patients were divided into three groups. Using an immune transmission turbidity method, the levels of serum complement C1q were detected to investigate the relationship between the level of serum complement C1q and the incidence and severity of acute ischemic stroke. The risk factors of these groups were calculated using a conditional logistic regression model. The assessment of neurological function impairment was carried out according to the National Institute of Health Stroke Scale. Then correlation anal- ysis was carried out between the level of serum complement C1q among patients with acute ischemic stroke and the degree of neurological function impairment. RESULTS:The results showed that the level of serum complement C1q was higher in the ischemic stroke group than in the control group. Using a conditional logistic regression model it was discovered that serum complement C1q was the independent pathogenic factor of cerebral infarction. There also was a decreasing trend in the level of serum complement C1q with the extension of the onset time and an increasing trend in the level of serum complement C1q with the increase in the maximum diameter of infarction volume. CONCLUSIONS:Serum complement C1q is an independent risk factor for acute outbreak of ischemic stroke, whose level is closely related to the outbreak and infarct size and neurological function impairment.

译文

背景:为了研究血清补体C1q水平与急性缺血性中风的风险和严重程度之间的关系,本研究共纳入154例急性缺血性中风患者和42名健康志愿者作为正常对照。
方法:根据中风的发作时间,将患者分为三组。采用免疫传递浊度法检测血清补体C1q水平,以探讨血清补体C1q水平与急性缺血性脑卒中的发生率和严重程度之间的关系。使用条件逻辑回归模型计算这些组的危险因素。根据美国国立卫生研究院卒中量表对神经功能损害进行评估。然后在急性缺血性卒中患者的血清补体C1q水平与神经功能损害程度之间进行相关分析。
结果:缺血性中风组血清补体C1q水平高于对照组。使用条件逻辑回归模型,发现血清补体C1q是脑梗死的独立致病因素。随着发作时间的延长,血清补体C1q的水平也有降低的趋势,并且随着梗死体积的最大直径的增加,血清补体C1q的水平也有增加的趋势。
结论:血清补体C1q是缺血性卒中急性发作的独立危险因素,其水平与发作,梗死面积和神经功能损害密切相关。

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