OBJECTIVE:To examine the relationships between the expression of protein Nm23 and surgical stage, histologic grade, histopathologic findings, and survival in women with endometrial carcinoma. METHODS:19 patients with lymph node involvement were matched with 24 patients without lymph node involvement and the best paraffin-embedded blocks were selected for Nm23 immunohistochemical staining. The slides were evaluated semiquantitatively according to their degree of cytoplasmic staining. Statistical analysis was performed to determine whether there was a relationship between Nm23 expression and surgical stage, histologic grade, depth of myometrial invasion, lymph node metastasis, and/or lymphovascular space involvement. Survival analysis was also performed. RESULTS:Slides from 15 patients (79%) with lymph node involvement and 22 patients (88%) without lymph node involvement were found to be positive for Nm23 (P=0.01). No significant relations were observed between Nm23 expression and surgical stage, histologic grade, depth of myometrial invasion, or lymphovascular space involvement. Nm23 expression was found to be significantly related to lower rates of lymph node metastasis and longer survival (P=0.02). CONCLUSION:Elevated Nm23 expression is related to lower rates of lymph node metastasis and longer survival.

译文

目的:探讨Nm23蛋白的表达与子宫内膜癌女性手术分期,组织学分级,组织病理学发现及生存之间的关系。
方法:将19例淋巴结受累患者与24例无淋巴结受累患者进行配对,并选择最佳石蜡包埋块进行Nm23免疫组化染色。根据细胞质染色的程度对玻片进行半定量评估。进行统计分析以确定Nm23表达与手术分期,组织学分级,肌层浸润深度,淋巴结转移和/或淋巴管间隙受累之间是否存在关系。还进行了生存分析。
结果:发现淋巴结受累的15例患者(79%)和无淋巴结受累的22例患者(88%)的玻片Nm23呈阳性(P = 0.01)。 Nm23表达与手术分期,组织学分级,肌层浸润深度或淋巴管间隙受累之间无显着相关性。发现Nm23表达与较低的淋巴结转移率和更长的存活率显着相关(P = 0.02)。
结论:Nm23表达升高与淋巴结转移率降低和生存期延长有关。

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