In 2003, the high level of chloroquine (CQ) treatment failure for uncomplicated Plasmodium falciparum malaria cases has led Senegal to adopt a new combination therapy with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ). From September through November 2004, we used the 14-day World Health Organization follow-up protocol to assess the therapeutic response in patients with uncomplicated P. falciparum malaria in an area of high prevalence of pfcrt T76 mutant allele and SP resistance mutations. Of the 82 patients who were recruited, 68 (82.9%) completed follow-up. The response of the patients to treatment was adequate clinical response for 63 out of 68 patients (92.6%), while five (7.4%) clinical failures were recorded, four early treatment failures, and one late treatment failure. The prevalence of the pfcrt T76 allele at day 0 was 59.5%. The two-sided Fisher's exact test did not show an association between pfcrt T76 allele and treatment failure (p=0.167). The transitory treatment is effective and safe. However, the presence of high levels of mutant alleles points out the need to closely monitor the new therapeutic regimen.

译文

:2003年,高氯氯喹(CQ)疗法在无并发症恶性疟原虫疟疾病例中的失败导致塞内加尔采用磺胺多辛-乙胺嘧啶和阿莫地喹(SP-AQ)的新联合疗法。从2004年9月到2004年11月,我们使用了为期14天的世界卫生组织随访方案来评估pfcrt T76突变等位基因和SP抗性突变高发地区的单纯性恶性疟原虫疟疾的治疗效果。在新招募的82位患者中,有68位(82.9%)完成了随访。 68例患者中有63例(92.6%)的患者对治疗的反应是足够的临床反应,而记录到5例(7.4%)临床失败,4例早期治疗失败和1例晚期治疗失败。 pfcrt T76等位基因在第0天的患病率为59.5%。双面Fisher精确检验未显示pfcrt T76等位基因与治疗失败之间的相关性(p = 0.167)。临时治疗是有效和安全的。然而,高水平的突变等位基因的存在表明需要密切监测新的治疗方案。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录