OBJECTIVE:To investigate the potential for domestic and wild populations of Aedes aegypti from Dakar and Kedougou to develop a disseminated infection after exposure to DENV-3 and DENV-1. METHODS:We have exposed sylvatic and urban population of Ae. aegypti from Senegal to bloomeals containing dengue serotype 1 and 3. At different incubation period, individual mosquito legs/wings and bodies were tested for virus presence using real time RT-PCR to estimate the infection and dissemination rates. RESULTS:The data indicated low susceptibility to DENV-3 (infection: 2.4-15.2%, and dissemination rates: 0-8.3%) and higher susceptibility to DENV-1 (infection and dissemination rates up to 50%). CONCLUSION:Aedes aegypti from Senegal seem able to develop a disseminated infection of DENV-1 and DENV-3. Further studies are needed to test their ability to transmit the two serotypes.

译文

目的:研究达喀尔和克杜古的埃及伊蚊的家养和野生种群在接触DENV-3和DENV-1后发展为传播性感染的潜力。
方法:我们暴露了Ae的动荡的城市人口。从塞内加尔到包括登革热血清型1和3的大片埃及埃及蚊。在不同的潜伏期,使用实时RT-PCR检测单个蚊子的腿/翼和尸体是否存在病毒,以评估感染和传播率。
结果:数据表明对DENV-3的敏感性较低(感染:2.4-15.2%,传播率:0-8.3%),对DENV-1的敏感性较高(感染和传播率高达50%)。
结论:塞内加尔的埃及伊蚊似乎能够传播DENV-1和DENV-3的传播感染。需要进一步研究以测试其传播两种血清型的能力。

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