One hundred and thirty-eight (138) pregnant women who had spontaneous abortions were screened for immunoglobulin G (IgG) antibodies to cardiolipin (aCL) by enzyme immunoassay (EIA). A total of 85 (61.6%) tested negative, while 53 (38.4%) had positive aCL test results. A review of the patients' hospital notes was conducted and comparisons were made between patients with moderate/high positive (21/138, 15.2%), those with low positive (32/138, 23.1%) and those with negative aCL results (85/138, 61.6%). The variables examined were a history of previous abortions, the number of previous fetal deaths and a past history of medical problems such as thrombosis or high blood pressure. No significant differences were found between the patients with moderate/high positive aCL; low positive aCL; and those with negative aCL test results for any of the clinical variables examined. In conclusion, the prevalence of positive IgG aCL tests was high in this cohort of patients with spontaneous abortion. However, intervention is not necessary in many of these patients who have only a positive aCL test, but none of the clinical conditions of the antiphospholipid syndrome.

译文

通过酶免疫法 (EIA) 筛选了一百三十八名 (138) 自然流产的孕妇的免疫球蛋白G (IgG) 抗心磷脂 (aCL) 抗体。共有85 (61.6%) 测试为阴性,而53 (38.4%) 的aCL测试结果为阳性。对患者的住院记录进行了回顾,并比较了中/高阳性 (21/138,15.2%),低阳性 (32/138,23.1%) 和aCL结果阴性 (85/138,61.6%) 的患者。检查的变量是以前的流产史,以前的胎儿死亡人数以及过去的疾病史,例如血栓形成或高血压。中/高aCL阳性的患者之间没有发现显着差异; 低阳性aCL; 和那些检查的任何临床变量的aCL测试结果阴性的患者。总之,在该自然流产患者队列中,IgG aCL测试阳性的患病率很高。但是,对于许多仅具有阳性aCL测试但没有抗磷脂综合征临床状况的患者,没有必要进行干预。

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