Diabetes mellitus is a metabolic disorder that affects millions of people worldwide. Present study highlights the antidiabetogenic property of Linum usitassimum active fraction (LU6) in streptozotocin (STZ) induced diabetic Swiss mice. Treatment with LU6 fraction showed improved glucose utilization with increase in liver glucose-6-phosphate dehydrogenase enzyme activity and normal glycogenesis in hepatic and muscle tissues. Reduction in pancreatic and intestinal glucosidase inhibitory activity was observed with LU6 treatment, indicating beneficial effects in reducing postprandial hyperglycemia (PPHG). Normalization of plasma insulin and C-peptide levels were observed in diabetic mice, indicating endogenous insulin secretion after the treatment with LU6. The histochemical and immunohistochemical analysis on pancreatic islets suggests the role of LU6 fraction in islet regeneration and insulin secretion as evident in increase functional pancreatic islets producing insulin. Furthermore, significant insulin producing islet formation was also observed in in vitro PANC-1 cells after LU6 treatment, indicating the cellular aggregates to be newly formed islets. This suggests the potential of LU6 fraction in the formation of new islets in vitro, as well as in vivo. Thus, LU6 can be used as a neutraceutical-based first-line treatment for diabetes.

译文

:Diabetes mellitus是一种代谢性疾病,可影响全球数百万人。本研究强调了链脲佐菌素(STZ)诱导的糖尿病瑞士小鼠中亚麻亚麻酸活性成分(LU6)的抗糖尿病作用。 LU6馏分的处理显示出改善的葡萄糖利用率,同时肝脏和肌肉组织中的6-磷酸葡萄糖葡萄糖脱氢酶活性增加,糖原生成正常。用LU6处理可观察到胰腺和肠道葡萄糖苷酶抑制活性的降低,表明在减少餐后高血糖(PPHG)方面有有益作用。在糖尿病小鼠中观察到血浆胰岛素和C肽水平的正常化,表明用LU6治疗后内源性胰岛素分泌。对胰岛的组织化学和免疫组化分析表明,LU6组分在胰岛再生和胰岛素分泌中的作用在增加生产胰岛素的功能性胰岛中很明显。此外,在LU6处理后的体外PANC-1细胞中也观察到了显着的产生胰岛素的胰岛形成,表明细胞聚集体是新形成的胰岛。这表明LU6馏分在体内和体外均会形成新的胰岛。因此,LU6可以用作以神经营养药物为基础的一线治疗药物。

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