Important advances in our understanding of the regulation of hepatic apolipoprotein B secretion have been made in the past year. A diverse group of studies have provided evidence that the inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors decreases the hepatic assembly and secretion of apolipoprotein B-containing lipoproteins. Apolipoprotein B kinetic studies performed in animals and human individuals indicate that inhibition of VLDL-apolipoprotein B secretion is an important mechanism whereby reductase inhibitors decrease plasma concentrations of these lipoproteins. Studies in cultured hepatocytes and in-vivo animal models have provided insights into how reduction of cholesterol synthesis decreases apolipoprotein B secretion. A decrease in hepatic acyl-coenzyme Acholesterol acyltransferase activity, secondary to reduced microsomal cholesterol concentrations, has been implicated.

译文

在过去的一年中,我们对调节肝载脂蛋白B分泌的认识取得了重要进展。各种各样的研究已经提供了证据,证明3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂对胆固醇合成的抑制作用会减少肝细胞的聚集和载脂蛋白B脂蛋白的分泌。在动物和人类体内进行的载脂蛋白B动力学研究表明,抑制VLDL-载脂蛋白B分泌是重要的机制,还原酶抑制剂可降低这些脂蛋白的血浆浓度。对培养的肝细胞和体内动物模型的研究提供了有关胆固醇合成减少如何减少载脂蛋白B分泌的见解。提示由于降低的微粒体胆固醇浓度,肝酰基辅酶胆固醇酰基转移酶活性降低。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录