The object location task is a new procedure evaluating spatial memory abilities in the rat. The aim of the present study was to characterize this behavioural paradigm by pharmacologic means. For this purpose, the effects of the muscarinic receptor antagonist scopolamine and the inhibitor of the nitric oxide synthase L-NAME on object location were assessed in the rat. In a first study, object location was impaired when the delay condition of 60-min was utilized. Subsequently, pre-training administration of scopolamine (0.2 mg/kg but not 0.07 mg/kg) induced delay-dependent performance deficits in this test. These impairments seem to be centrally mediated since the peripheral muscarinic receptor antagonist methylscopolamine (0.2 mg/kg) did not affect object location under the same conditions. Finally, pre-training treatment with L-NAME (30 mg/kg but not 10 mg/kg) also induced delay-dependent performance deficits in the object location task. These results indicate that the object location test is sensitive to pharmacological treatment and could be used for assessing the therapeutic potential of promnesic compounds.

译文

:对象定位任务是一种评估大鼠空间记忆能力的新程序。本研究的目的是通过药理学方法表征这种行为范例。为此目的,在大鼠中评估毒蕈碱受体拮抗剂东pol碱和一氧化氮合酶L-NAME的抑制剂对物体位置的影响。在第一个研究中,当使用60分钟的延迟条件时,对象的位置会受到损害。随后,在该测试中,东pol碱的训练前给药(0.2 mg / kg而不是0.07 mg / kg)引起了延迟依赖的性能缺陷。由于周围毒蕈碱受体拮抗剂甲基东pol碱(0.2 mg / kg)在相同条件下不影响物体位置,因此这些损伤似乎是中央介导的。最后,使用L-NAME(30 mg / kg但不是10 mg / kg)进行预训练治疗也会在对象定位任务中引起延迟依赖的性能缺陷。这些结果表明,对象位置测试对药理学治疗敏感,可用于评估Promnesic化合物的治疗潜力。

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