Alzheimer's disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity in the affected regions. In this study, we investigated the effects of obovatol on memory dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day) attenuated scopolamine (1 mg/kg, i.p.)-induced amnesia in a dose-dependent manner, as revealed by the Morris water maze test and step-through passive avoidance test. Mechanism studies exhibited that obovatol dose-dependently alleviated scopolamine-induced increase in Aβ generation and β-secretase activity in the cortex and hippocampus. Obovatol also attenuated scopolamine-induced rise in AChE activity in the cortex and hippocampus. Obovatol might rescue scopolamine-mediated impaired learning and memory function by attenuating Aβ accumulation and stabilizing cholinergic neurotransmission, which suggests that the natural compound could be a useful agent for the prevention of the development or progression of AD neurodegeneration.

译文

:阿尔茨海默氏病(AD)是老年人痴呆症最普遍的病因。该疾病的病理特征是β-淀粉样肽(Aβ)的细胞外沉积,胆碱能神经退行性变和受影响区域乙酰胆碱酯酶(AChE)活性的升高。在这项研究中,我们调查了小ova酚对东碱引起的记忆障碍的影响。 Obovatol(0.2、0.5和1 mg / kg,共7天)以剂量依赖的方式减弱了东pol碱(1 mg / kg,i.p.)引起的健忘症,如莫里斯水迷宫测试和逐步被动回避测试所揭示的那样。机制研究表明,奥波托尔剂量依赖性地减轻了东pol碱所致的皮质和海马中Aβ生成和β-分泌酶活性的增加。 Obovatol还减弱了东pol碱诱导的皮质和海马中AChE活性的升高。 Obovatol可能通过减弱Aβ积累和稳定胆碱能神经传递来拯救东pol碱介导的学习和记忆功能受损,这表明该天然化合物可能是预防AD神经变性发展或进程的有用药物。

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