To evaluate the usefulness of pirenzepine for diagnostic double-contrast barium enema study of the large bowel, pirenzepine and scopolamine methyl bromide (SMB) were compared in a single, blind, randomized trial. Sixty consecutive patients were enrolled in the study. Quantitative analysis of bowel distention was done by measuring the maximum diameter of the transverse colon before and after drug administration. Four independent observers blindly evaluated distention and mucosal coating of the large bowel and global quality of the images. No differences were found in the diagnostic performance between the two drugs. However, pirenzepine induced a slight but significantly larger distention of the large bowel (68 +/- 12 vs. 65 +/- 8 mm, p = 0.02). Heart rate and rhythm during the study were recorded by ECG. SMB induced tachycardia in all patients (from 72 +/- 15 to 98 +/- 24 beats/min, p < 0.01), whereas pirenzepine did not (from 76 +/- 13 to 78 +/- 20, p = NS). After SMB, one-patient exhibited faintness, and some patients complained of visual accommodation defects, dryness of the mouth, and dizziness. Pirenzepine had a diagnostic performance similar to SMB in avoiding adverse effects elicited by SMB.

译文

为了评估哌仑西平在大肠诊断性双对比钡灌肠研究中的有用性,在一项单盲,随机试验中比较了吡仑西平和东pol碱甲基溴(SMB)。连续六十名患者被纳入研究。通过在给药之前和之后测量横结肠的最大直径来进行肠扩张的定量分析。四个独立的观察者盲目评估了大肠的扩张和粘膜涂层以及图像的整体质量。两种药物的诊断性能没有发现差异。然而,哌仑西平引起大肠的轻微但明显更大的扩张(68 /-12对65 /-8 mm,p = 0.02)。通过ECG记录研究期间的心律和心律。 SMB诱发所有患者的心动过速(从72 /-15到98 /-24次/分钟,p <0.01),而哌仑西平则没有(从76 /-13到78 /-20,p = NS)。 SMB后,一名患者出现晕厥,有些患者主诉视觉适应性缺陷,口干和头晕。哌仑西平在避免SMB引起的不良反应方面具有与SMB类似的诊断性能。

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