OBJECTIVES:Cognitive deficits are one of the frequent symptoms accompanying epilepsy or its treatment. METHODS:In this study, the effect on cognition of intraperitoneally administered antiepileptic drug, pregabalin (10 mg/kg), was investigated in scopolamine-induced memory-impaired mice in the passive avoidance task and Morris water maze task. The effect of scopolamine and pregabalin on animals' locomotor activity was also studied. RESULTS:In the retention phase of the passive avoidance task, pregabalin reversed memory deficits induced by scopolamine (p < 0.05). During the acquisition phase of the Morris water maze pregabalin-treated memory-impaired mice performed the test with longer escape latencies than the vehicle-treated mice (significant at p < 0.05 on Day 5, and at p < 0.001 on Day 6). There were no differences in this parameter between the scopolamine-treated control group and pregabalin-treated memory-impaired mice, which indicated that pregabalin had no influence on spatial learning in this task. During the probe trial a significant difference (p < 0.05) was observed in terms of the mean number of target crossings between vehicle-treated mice and pregabalin-treated memory-impaired mice but there was no difference between the scopolamine-treated control group and mice treated with pregabalin + scopolamine. Pregabalin did not influence locomotor activity increased by scopolamine. DISCUSSION:In passive avoidance task, pregabalin reversed learning deficits induced by scopolamine. In the Morris water maze, pregabalin did not influence spatial learning deficits induced by scopolamine. These results are relevant for epileptic patients treated with pregabalin and those who use it for other therapeutic indications (anxiety, pain).

译文

目的:认知功能障碍是伴随癫痫或其治疗的常见症状之一。
方法:在这项研究中,在被动回避任务和莫里斯水迷宫任务中,研究了东碱诱导的记忆力受损小鼠腹腔内施用抗癫痫药物普瑞巴林(10μmg/ kg)对认知的影响。还研究了东pol碱和普瑞巴林对动物运动能力的影响。
结果:在被动回避任务的保留阶段,普瑞巴林逆转了东pol碱引起的记忆障碍(p <0.05)。在莫里斯水迷宫的采集阶段中,用普瑞巴林治疗的记忆力受损小鼠比用载体治疗的小鼠进行逃逸潜伏期更长的测试潜伏期(在第5天的p << 0.05,在第6天的p << 0.001显着)。东碱治疗的对照组和普瑞巴林治疗的记忆受损小鼠之间的此参数没有差异,这表明普瑞巴林在此任务中对空间学习没有影响。在探针试验期间,在媒介物处理的小鼠和普瑞巴林治疗的记忆力受损的小鼠之间的平均目标交叉数方面观察到显着差异(p <0.05),但东pol碱治疗的对照组和小鼠之间没有显着差异用普瑞巴林东pol碱治疗。普瑞巴林不影响东pol碱所增加的运动活性。
讨论:在被动回避任务中,普瑞巴林逆转了东pol碱引起的学习缺陷。在莫里斯水迷宫中,普瑞巴林不影响东pol碱引起的空间学习障碍。这些结果与普瑞巴林治疗的癫痫患者以及将其用于其他治疗适应症(焦虑,疼痛)的患者有关。

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