Kalopanax pictus (Araliaceae) is a deciduous tree distributed in Korea, Japan, and China. The stem bark of K. pictus has been functionally used as a traditional crude drug for the treatment of various inflammatory diseases. In the present study, we describe the inhibitory effects of oleanane-type triterpenes and saponins isolated from the stem bark of K. pictus on production of pro-inflammatory cytokines in LPS-stimulated bone marrow-derived dendritic cells. Of the compounds tested, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3β,6β,23-trihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (3), nipponogenin E (6), 3β,6β,23-trihydroxyolean-12-en-28-oic acid (7), and caulophyllogenin (19) significantly inhibited the production of IL-12 p40 and IL-6 with IC50 values ranging from 3.3 to 9.1 μM. Compounds 2, 3, 7, and 19 significantly suppressed the secretion of TNF-α with IC50 ranging from 8.8 to 20.0 μM. These data provide scientific support for the use of K. pictus stem bark and its triterpene and saponin components in the inhibition of pro-inflammatory cytokine secretion, including IL-12 p40, IL-6, and TNF-α, and for prevention and treatment of inflammatory diseases.

译文

:Kalopanax pictus((科)是分布在韩国,日本和中国的落叶乔木。 Pic。K. pictus的茎皮已在功能上用作治疗各种炎性疾病的传统原料药。在本研究中,我们描述了从苦参根茎皮中分离得到的齐墩果烷型三萜和皂苷对LPS刺激的骨髓源性树突状细胞促炎性细胞因子产生的抑制作用。在测试的化合物中,16,23,29-三羟基-3-氧代-油酸-12-en-28-油酸(1),4,23,29-三羟基-3,4-seco-油酸-12-en -3-oate-28-oic acid(2),3β,6β,23-trihydroxyolean-12-en-28-oic acid28-O-β-D-glucopyranoside(3),nipponogenin E(6),3β, 6β,23-三羟基油酸酯-12-en-28-油酸(7)和花椰菜素(19)显着抑制IL-12 p40和IL-6的产生,IC50值在3.3至9.1μM之间。化合物2、3、7和19显着抑制TNF-α的分泌,IC50为8.8至20.0μM。这些数据提供了对K. pictus茎皮及其三萜和皂苷成分在抑制促炎性细胞因子分泌(包括IL-12 p40,IL-6和TNF-α)以及预防和治疗中的用途的科学支持。炎性疾病。

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