Affinity maturation of antibodies during the course of an adaptive immune response requires germinal centre (GC) formation within B-cell follicles. Much of the current understanding of GC function has been derived from histology, but these static views have left unresolved many questions about cell movement in GCs. In this Progress article, we describe how several recent studies using time-resolved multiphoton microscopy to track GC B-cell movement within lymph nodes have shed light on the processes that influence GC B-cell dynamics.

译文

在适应性免疫反应过程中,抗体的亲和力成熟需要B细胞卵泡内生发中心(GC)的形成。当前对GC功能的大多数了解都来自组织学,但是这些静态视图尚未解决许多有关GC中细胞运动的问题。在这篇“进步”文章中,我们描述了最近几项使用时间分辨多光子显微镜跟踪淋巴结内GC B细胞运动的研究如何阐明了影响GC B细胞动力学的过程。

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