Our previous studies showed that both Sae and Fur are required for the induction of eap and emp expression in low iron. In this study, we show that expression of sae is also iron-regulated, as sae expression is activated by Fur in low iron. We also demonstrate that both Fur and Sae are required for full induction of the oxidative stress response and expression of non-covalently bound surface proteins in low-iron growth conditions. In addition, Sae is required for the induced expression of the important virulence factors isdA and isdB in low iron. Our studies also indicate that Fur is required for the induced expression of the global regulators Agr and Rot in low iron and a number of extracellular virulence factors such as the haemolysins which are also Sae- and Agr-regulated. Hence, we show that Fur is central to a complex regulatory network that is required for the induced expression of a number of important S. aureus virulence determinants in low iron.

译文

:我们以前的研究表明,Sae和Fur都需要在低铁条件下诱导eap和emp表达。在这项研究中,我们显示sae的表达也是铁调节的,因为sae的表达被低铁中的Fur激活。我们还证明,在低铁生长条件下,完全诱导氧化应激反应和表达非共价结合的表面蛋白都需要Fur和Sae。另外,在低铁条件下,重要的毒力因子isdA和isdB的诱导表达需要Sae。我们的研究还表明,在低铁和许多细胞外毒力因子(如溶血素(也受Sae和Agr调节))的诱导表达中,Fur是诱导整体调节剂Agr和Rot表达所必需的。因此,我们表明,对于低铁中许多重要的金黄色葡萄球菌毒力决定因子的诱导表达,复杂的调控网络至关重要。

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