G9P[8] rotavirus A (RVA) has been identified as the predominant genotype circulating in Yunnan, China. To elucidate the molecular characteristics of its genetic composition at the whole-genome level, the genomes of 12 strains isolated from paediatric patients with diarrhoea were fully sequenced and characterized. Eleven of the 12 strains were genotyped as G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1, which is closely related to the Wa-like genotype 1 constellation. In contrast, one strain was genotyped as G9-P[8]-I1-R1-C1-M1-A1-N2-T1-E1-H1, with the NSP2 gene characterized as a DS-1 like genotype. Bayesian phylogenetic analysis indicated that G9 strains had emerged in 1932 with an estimated average evolutionary rate of 1.63×10-3 substitutions/site/year. Considering the high prevalence and fast evolutionary rate of G9P[8] rotaviruses, our results suggest that G9P[8] RVA should be strictly monitored in China.

译文

:G9P [8]轮状病毒A(RVA)已被确定为中国云南省流行的主要基因型。为了阐明其全基因组水平的遗传组成的分子特征,对从腹泻儿科患者中分离出的12个菌株的基因组进行了完整的测序和鉴定。 12个菌株中的11个被定型为G9-P [8] -I1-R1-C1-M1-A1-N1-T1-E1-H1,这与Wa样基因型1星座密切相关。相反,一种菌株的基因型为G9-P [8] -I1-R1-C1-M1-A1-N2-T1-E1-H1,NSP2基因的特征为DS-1样基因型。贝叶斯系统发育分析表明,G9菌株于1932年出现,估计平均进化速率为1.63×10-3个置换/位点/年。考虑到G9P [8]轮状病毒的高流行率和高进化速度,我们的结果表明,应在中国严格监测G9P [8] RVA。

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