OBJECTIVE:To assess whether interindividual variation in renal plasma flow or in its response to angiotensin II infusion is associated with interindividual differences in blood pressure in a population-based sample of 287 non-Hispanic whites (143 women and 144 men), aged 20-49.9 years.

METHODS:After seven days of eating a high-sodium diet (260 mmol/day), the renal plasma flow was determined by measuring the clearance of p-aminohippurate before and after infusion of 3 ng/kg per min angiotensin II. Multiple linear regression methods were used to assess whether measures of the renal plasma flow and of its response to angiotensin II infusion were predictive of systolic or diastolic blood pressures measured prior to administration of the high-sodium diet, on day 6 of the high-sodium diet, or during the renal clearance procedure on day 7 prior to angiotensin II infusion.

RESULTS:There was some evidence that measures of the renal plasma flow and of its response to angiotensin II infusion during the high-sodium diet were statistically significant predictors of measures of blood pressure in women; there was less evidence for this for blood pressures in men. Interindividual variation in measures of the renal plasma flow and of its response to angiotensin II infusion explained less than 10% of the interindividual variation in any measure of the blood pressure in both sexes.

CONCLUSION:These results suggest that interindividual variation in renal plasma flow ad in its response to angiotensin II infusion during a high-sodium diet will be of limited utility in elucidating the basis for interindividual differences in blood pressure.

译文

目标:在以人群为基础的287名非西班牙裔白人(143名女性和144名男性,年龄20-49.9岁。

方法:进食高钠饮食(260 mmol /天)7天后,通过测量来确定肾脏血浆流量输注前后每分钟3 ng / kg血管紧张素II对对氨基马尿酸盐的清除率。使用多种线性回归方法评估在高钠饮食第6天服用高钠饮食之前测量的肾血浆流量及其对血管紧张素II输注的反应是否可预测收缩压或舒张压饮食,或在输注血管紧张素II的第7天进行肾脏清除手术。高钠饮食期间的输注是女性血压测量的统计学上显着的预测因子;男性血压下降的证据较少。肾脏血浆流量及其对血管紧张素II输注反应的个体差异解释了男女血压测量中个体差异的不足10%。

结论 >:这些结果表明,在高钠饮食期间,肾血浆流量的个体差异及其对血管紧张素II输注的反应在阐明个体间血压差异的依据方面将发挥有限的作用。

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