BACKGROUND:Frequent germ line cells mutations were previously demonstrated to be associated with aging. This suggests a higher incidence of childhood cancer among children of older parents. A population-based cohort study of parental ages and other prenatal risk factors for five main childhood cancers was performed with the use of a linkage between several national-based registries. METHODS:In total, about 4.3 million children with their parents, born between 1961 and 2000, were included in the study. Multivariate Poisson regression was used to obtain the incidence rate ratios (IRR) and 95% confidence interval (CI). Children <5 years of age and children 5-14 years of age were analysed independently. RESULTS:There was no significant result for children 5-14 years of age. For children <5 years of age, maternal age were associated with elevated risk of retinoblastoma (oldest age group's IRR = 2.39, 95%CI = 1.17-4.85) and leukaemia (oldest age group's IRR = 1.44, 95%CI = 1.01-2.05). Paternal age was significantly associated with leukaemia (oldest age group's IRR = 1.31, 95%CI = 1.04-1.66). For central nervous system cancer, the effect of paternal age was found to be significant (oldest age group's IRR = 1.69, 95%CI = 1.21-2.35) when maternal age was included in the analysis. CONCLUSION:Our findings indicate that advanced parental age might be associated with an increased risk of early childhood cancers.

译文

背景:以前已证明生殖细胞系细胞频繁突变与衰老有关。这表明年龄较大的父母的孩子中儿童期癌症的发生率更高。利用几个国家注册中心之间的联系,对五种主要的儿童期癌症的父母年龄和其他产前危险因素进行了基于人群的队列研究。
方法:该研究总共纳入了430万名带父母的孩子,他们于1961年至2000年之间出生。使用多元Poisson回归获得发病率比(IRR)和95%置信区间(CI)。对5岁以下的儿童和5-14岁的儿童进行了独立分析。
结果:5-14岁的儿童没有明显的结果。对于<5岁的儿童,产妇的年龄与视网膜母细胞瘤(最高年龄组的IRR = 2.39,95%CI = 1.17-4.85)和白血病(最高年龄组的IRR = 1.44,95%CI = 1.01-2.05)的风险升高相关)。父亲年龄与白血病显着相关(最高年龄组的IRR = 1.31,95%CI = 1.04-1.66)。对于中枢神经系统癌症,分析中纳入了母亲年龄,发现父亲年龄的影响很明显(最大年龄组的IRR = 1.69,95%CI = 1.21-2.35)。
结论:我们的研究结果表明,高龄的父母年龄可能与儿童早期癌症的风险增加有关。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录