Tumor necrosis factor superfamily member 4 (TNFSF4) plays a key role in the process of atherosclerosis, a common risk factor for both myocardial and cerebral infarctions. Recent studies indicate that the single nucleotide polymorphism (SNP) rs3850641 in TNFSF4 is associated with higher risk of myocardial infarction, but little is known about the association between TNFSF4 variation and cerebral infarction (CI). A case-control study involving 385 CI patients and 385 age-matched, sex-matched non-CI controls was conducted in a Chinese population, only the most common subtype, atherosclerosis CI, was recruited. Two SNPs of TNFSF4, rs3850641 and rs3861950, were genotyped by the TaqMan SNP genotyping method, and verified partly by genomic DNA sequencing. The results revealed a significant allelic association between rs3861950 and CI (Odds ration = 1.733, 95 % confidence interval = 1.333-2.254, P = 0.000). Genotypic association analysis demonstrated that the CC genotype of rs3861950 confers susceptibility to CI (Odds ration = 2.896, 95 % confidence interval = 1.368-6.132), and it was associated with a significantly higher risk of ischemic stroke (Odds ration = 3.520, 95 % confidence interval = 1.546-8.015, P = 0.003) after adjusting for the other confirmed risk factors such as the history of hypertension, diabetes, CAD, smoking and alcohol drinking. While the odds ratio of the T allele to the C allele was 1.733 (95 % confidence interval: 1.333-2.254). However, there was no significant association between rs3850641 and CI (Odds ration = 1.288, 95 % confidence interval = 0.993-1.670, P = 0.056). TNFSF4 gene polymorphism rs3861950, but not rs3850641, is associated with the risk of atherosclerosis CI in a Chinese population.

译文

:肿瘤坏死因子超家族成员4(TNFSF4)在动脉粥样硬化的过程中起着关键作用,动脉粥样硬化是心肌和脑梗塞的常见危险因素。最近的研究表明,TNFSF4中的单核苷酸多态性(SNP)rs3850641与较高的心肌梗死风险相关,但对TNFSF4变异与脑梗死(CI)之间的关联知之甚少。在中国人群中进行了一项涉及385名CI患者和385名年龄匹配,性别匹配的非CI对照的病例对照研究,仅招募了最常见的亚型动脉粥样硬化CI。通过TaqMan SNP基因分型方法对TNFSF4的两个SNP rs3850641和rs3861950进行基因分型,并通过基因组DNA测序部分验证。结果显示rs3861950与CI之间存在显着的等位基因关联(赔率= 1.733,95%置信区间= 1.333-2.254,P = 0.000)。基因型关联分析表明,rs3861950的CC基因型赋予CI易感性(赔率= 2.896,95%置信区间= 1.368-6.132),并且与缺血性中风的风险显着相关(赔率= 3.520,95%在调整其他已确认的危险因素(例如高血压,糖尿病,CAD,吸烟和饮酒)后,置信区间= 1.546-8.015,P = 0.003)。 T等位基因与C等位基因的比值比为1.733(95%置信区间:1.333-2.254)。但是,rs3850641与CI之间没有显着关联(赔率= 1.288,95%置信区间= 0.993-1.670,P = 0.056)。 TNFSF4基因多态性rs3861950(而不是rs3850641)与中国人群的动脉粥样硬化CI风险相关。

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