AIMS:We tested whether brain event-related potentials (ERPs) are normal in children with congenital hypothyroidism (CH) after early high-dose levothyroxine treatment. METHODS:Auditory ERPs were recorded in 33 normal controls and in 15 children with CH at 5 years 9/12. Based on bone maturation at diagnosis, the CH group was divided into severe (n = 8) and moderate (n = 7) subgroups. CH patients were treated at a median age of 14 days with a mean initial dose of levothyroxine of 11.6 microg/kgxday. Two ERP components (N100 and N200) were measured and clinical follow-up variables collected. RESULTS:The functional anatomical and cognitive organisation of the auditory system, as revealed by the analyses of ERP measures, did not differ between CH and controls, or between severe and moderate CH subjects. However, N200 latency was globally longer in the CH than in the control group (p = 0.01) and was positively correlated with the over-treatment index (r = 0.61; p < 0.05) and verbal IQ. N200 amplitude was negatively correlated with initial dose (r = -0.74; p < 0.005). CONCLUSION:These data suggest that sensitive tools such as ERPs can reveal differences between CH and controls and relate these differences to the adequacy of treatment of CH.

译文

目的:我们测试了大剂量左甲状腺素早期治疗后先天性甲状腺功能减退症(CH)儿童的脑事件相关电位(ERP)是否正常。
方法:在33名正常对照者和15名5岁9/12的CH儿童中记录了听诊ERP。根据诊断时的骨成熟度,将CH组分为严重(n = 8)和中度(n = 7)亚组。 CH患者的中位年龄为14天,左甲状腺素的平均初始剂量为11.6 microg / kgxday。测量了两个ERP组件(N100和N200),并收集了临床随访变量。
结果:ERP措施的分析显示,听觉系统的功能解剖和认知组织在CH和对照之间,或在重度和中度CH患者之间没有差异。但是,CH中的N200潜伏期总体上比对照组长(p = 0.01),并且与过度治疗指数(r = 0.61; p <0.05)和言语智商呈正相关。 N200振幅与初始剂量呈负相关(r = -0.74; p <0.005)。
结论:这些数据表明,诸如ERPs之类的敏感工具可以揭示CH与对照之间的差异,并将这些差异与CH的治疗充分性联系起来。

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