BACKGROUND/AIMS:MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. METHODS:We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. RESULTS:For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group. However, in stratified analysis by ethnicity, we found that rs11614913 T allele was a risk factor for Asian PCa patients. CONCLUSIONS:Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants. Moreover, miR-146a rs2910164 polymorphism was related to PCa prognosis.

译文

背景/目的:微小RNA(miRNA)是一类小的非编码RNA分子,在转录和翻译调控中起着重要作用。关于miRNA SNP与前列腺癌(PCa)风险之间关系的已发表数据尚无定论。
方法:我们对包括2,227例患者和2,331例对照受试者在内的所有可用研究进行了荟萃分析,以评估microRNA的三种常见遗传变异对前列腺癌风险的影响。具有95%置信区间(CI)的几率(OR)用于研究关联的强度。
结果:对于miR-499多态性,在杂合子比较和优势遗传模型中,尤其是亚洲人群中,观察到rs3746444 A> G多态性与PCa风险之间存在显着关联。对于miR-146a多态性,纯合子比较显示,rs2910164 CC基因型与亚洲人群PCa风险降低相关。此外,rs2910164 CC基因型在Gleason评分<7的亚组中每周有更高的百分比值。在按肿瘤分期进行的亚组分析中,局部前列腺癌也显示了相似的结果。对于miR-196a2多态性,在整个组中未观察到此变异与PCa风险之间的关联。但是,在按种族进行的分层分析中,我们发现rs11614913 T等位基因是亚洲PCa患者的危险因素。
结论:miR-196a2 rs11614913,miR-146a rs2910164和miR-499 rs3746444的多态性可能会导致亚洲后裔患上前列腺癌的风险。此外,miR-146a rs2910164多态性与PCa的预后有关。

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