BACKGROUND:Evidence has shown that single nucleotide polymorphism located in pre-miRNA or mature microRNA may modify various biological processes and affect the processing of carcinogenesis. Published results about the association between miR-146a rs2910164 G/C polymorphism and human gastric cancer susceptibility are inconclusive. The aim of this study was to acquire a more precise effect of the association between the miR-146a rs2910164 polymorphism and gastric risk by meta-analysis. METHODS:Eligible genetic association studies were searched from PubMed, Web of Knowledge and Chinese Biomedicine Database on human subject. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism with susceptibility to gastric cancer. RESULTS:Nine eligible studies that included a total of 3,885 gastric cancer patients and 5,396 controls were identified in the present meta-analysis. The overall OR indicated a potential association between rs2910164 polymorphism and GC but the effect was not statistically significant (GG vs. CG/CC:OR = 1.076, 95% CI 0.925-1.251, P = 0.342). When stratifying for population, the result showed that miR-146a rs2910164 GG genotype was associated with increased gastric cancer risk among Chinese in recessive model (GG vs. CG/CC:OR = 1.171, 95% CI 1.050-1.306, P = 0.005). Besides, no significant difference was found in gender, smoking, location, metastasis of lymph node and Laurèn's classification. CONCLUSIONS:The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures.

译文

背景:证据表明,位于pre-miRNA或成熟microRNA中的单核苷酸多态性可能会改变各种生物学过程并影响致癌过程。关于miR-146a rs2910164 G / C多态性与人胃癌易感性之间关系的已发表结果尚无定论。这项研究的目的是通过荟萃分析获得miR-146a rs2910164多态性与胃癌风险之间关联的更精确效果。
方法:从PubMed,Web of Knowledge和中国生物医学数据库中检索有关人类受试者的合格遗传关联研究。进行了miR-146a rs2910164 G / C多态性与胃癌易感性相关性的定量数据综合。
结果:本荟萃分析共鉴定出9项合格研究,共3885例胃癌患者和5396例对照患者。总体OR表示rs2910164多态性与GC之间存在潜在的关联,但效果无统计学意义(GG vs.
CG / CC:OR = 1.076,95%CI 0.925-1.251,P = 0.342)。当按人群分层时,结果显示,在隐性模型中,miR-146a rs2910164 GG基因型与中国胃癌风险增加相关(GG vs.
CG / CC:OR = 1.171,95%CI 1.050-1.306,P = 0.005)。此外,在性别,吸烟,淋巴结转移,淋巴结转移和劳伦分类方面无显着差异。
结论:目前的荟萃分析表明,根据已发表的文献,中国人miR-146a rs2910164 GG基因型与胃癌易感性之间的风险增加。

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