Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.

译文

:背景。编码microRNA的基因中的单核苷酸多态性(SNP)可能在胃癌的发生中起重要作用。据报道,miR-146a中常见的SNP rs2910164和miR-196a2中常见的rs11614913与胃癌的易感性有关。发表的结果仍然没有定论,甚至是有争议的。进行荟萃分析以定量评估两种常见SNP与胃癌风险之间的潜在关联。方法。在多个基于互联网的电子数据库中进行了全面的文献搜索。提取了来自12项合格研究的数据,以估计合并的优势比(OR)和95%的置信区间(95%CI)。结果。 rs2910164的C等位基因与杂合子模型和显性模型中降低的胃癌风险相关,而rs11614913表明无显着相关性。亚组分析表明,rs2910164和rs11614913的C等位基因可能在显性模型和隐性模型中分别降低对弥漫型胃癌的易感性,而rs11614913在显性模型中增加肠型胃癌的易感性。结论。在某些遗传模型和特定类型的癌症中,SNP rs2910164和rs11614913可能对胃癌风险有影响。应该考虑进行进一步设计良好的研究,以验证潜在的效果。

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