BACKGROUND:Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association. METHODS:PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included. RESULTS:We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models. CONCLUSIONS:This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.

译文

背景:多项研究报告了miR-146a rs2910164 G> C多态性作为几种消化道癌症的易感因素的作用。但是,结果一直存在争议。因此,我们进行了本次荟萃分析,以获得最可靠的关联估计。
方法:检索PubMed,Embase和Web of Science数据库。提取具有95%置信区间(CI)的原始比值比(OR)并合并,以评估miR-146a rs2910164 G> C多态性与消化道癌症风险之间的关联强度。根据搜索标准,总共纳入了四项合格研究,包括3447例病例和5,041例对照。
结果:我们观察到,将所有研究纳入荟萃分析后,miR-146a rs2910164 G> C多态性与消化道癌症风险没有显着相关性。尽管我们发现miR-146a rs2910164多态性与胃癌无关,但它与肝细胞癌风险显着相关(纯合子显性模型:OR = 1.40,95%CI = 1.04-1.87)。在按族裔进行的分层分析中,在中国人群中,等位基因对比模型(OR = 1.25; 95%CI = 1.12-1.38),纯合子显性模型(OR = 1.62; 95%CI = 1.28-2.04)之间存在显着关联。 ),以及隐性模型(OR = 1.38; 95%CI = 1.16-1.64)。但是,与亚洲人群的研究表明,所有遗传模型之间均无显着关联。
结论:这项荟萃分析表明,miR-146a rs2910164 G> C多态性是中国消化道癌的低渗透危险因素。

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