BACKGROUND:Many studies investigated the association between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases. However, the results were inconsistent.
METHODS:We searched the PubMed, EMBASE, Cochrane library, Web of Science, Chinese National Knowledge Infrastructure, VIP, and Wanfang databases for appropriate studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations. Heterogeneity, sensitivity, and publication bias were conducted to measure the robustness of our findings.All analyses were based on previous published studies, thus, no ethical approval and patient consent are required.
RESULTS:We conducted a meta-analysis to evaluate the relationship between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases. A total of 26 related studies involving 11,602 cases and 14,016 controls were identified and included in our meta-analysis. After considering the heterogeneity of the global analysis, we inferred that rs2910164 polymorphisms were associated with a lower risk of coronary heart disease (CHD) significantly in all genetic models. In addition, it was also found that the miR-146a rs2910164 polymorphisms were associated with the low risk of ischemic cardio-cerebrovascular diseases in large sample size subgroup analysis.
CONCLUSION:These results indicate that miR-146a rs2910164 polymorphisms were significantly associated with a lower risk of ischemic cardio-cerebrovascular. The miR-146a rs29101164 might be recommended as a predictor for susceptibility of ischemic cardio-cerebrovascular diseases.
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【Associations between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases.].
【miR-146a rs2910164多态性与缺血性心脑血管疾病风险之间的关联。】
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DOI：10.1097/MD.0000000000017106文章类型：杂志文章
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背景：许多研究调查了miR-146a rs2910164多态性与缺血性心脑血管疾病风险之间的关系。但是，结果不一致。
方法：我们在PubMed，EMBASE，Cochrane图书馆，Web of Science，中国国家知识基础设施，VIP和Wanfang数据库中进行搜索，以进行适当的研究。计算具有95％置信区间（CI）的几率（OR）以评估关联。进行异质性，敏感性和发表偏倚来衡量我们研究结果的稳健性。所有分析均基于先前发表的研究，因此无需获得伦理学批准和患者同意。
结果：我们进行了荟萃分析，以评估miR-146a rs2910164多态性与缺血性心脑血管疾病风险之间的关系。总共鉴定了26项相关研究，涉及11,602例病例和14,016例对照，并将其纳入我们的荟萃分析。考虑到全局分析的异质性后，我们推断在所有遗传模型中，rs2910164多态性与冠心病（CHD）的较低风险显着相关。此外，还发现在大样本亚组分析中，miR-146a rs2910164多态性与缺血性心脑血管疾病的低风险相关。
结论：这些结果表明，miR-146a rs2910164多态性与缺血性心脑血管的低风险显着相关。可能建议将miR-146a rs29101164作为缺血性心脑血管疾病易感性的预测指标。
方法：我们在PubMed，EMBASE，Cochrane图书馆，Web of Science，中国国家知识基础设施，VIP和Wanfang数据库中进行搜索，以进行适当的研究。计算具有95％置信区间（CI）的几率（OR）以评估关联。进行异质性，敏感性和发表偏倚来衡量我们研究结果的稳健性。所有分析均基于先前发表的研究，因此无需获得伦理学批准和患者同意。
结果：我们进行了荟萃分析，以评估miR-146a rs2910164多态性与缺血性心脑血管疾病风险之间的关系。总共鉴定了26项相关研究，涉及11,602例病例和14,016例对照，并将其纳入我们的荟萃分析。考虑到全局分析的异质性后，我们推断在所有遗传模型中，rs2910164多态性与冠心病（CHD）的较低风险显着相关。此外，还发现在大样本亚组分析中，miR-146a rs2910164多态性与缺血性心脑血管疾病的低风险相关。
结论：这些结果表明，miR-146a rs2910164多态性与缺血性心脑血管的低风险显着相关。可能建议将miR-146a rs29101164作为缺血性心脑血管疾病易感性的预测指标。
