MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNFα and TGFβ up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.

译文

:MicroRNA是短的非编码RNA,可通过RNA干扰调节基因表达。口腔鳞状细胞癌(OSCC)是世界范围内普遍存在的恶性肿瘤。据报道,miR-146a调节Toll样受体和细胞因子信号传导,这对于炎症和肿瘤的发生均至关重要。这项研究确定了槟榔提取物,TNFα和TGFβ上调OSCC细胞中的miR-146a。 miR-146a表达的增加增强了OSCC细胞的致癌性。此外,位于miR-146a前的G到C多态性(rs2910164)与miR-146a的功能改变有关,在结节受累程度更高的OSCC患者中明显更为普遍。我们的分析还表明,携带C基因多态性的OSCC组织中miR-146a的表达较高。本研究得出结论,该疾病患者中mir-146a前C变体的较高患病率与OSCC进展相关。

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