The localized activation of coagulation in vascular malformations can lead to a consumptive coagulopathy characterized by elevated D-dimers and a consumption of fibrinogen and platelets, eventually giving rise to a bleeding tendency. By reducing coagulation activation, anticoagulant treatment with heparin is able to limit this haemostatic dysregulation and the associated bleeding diathesis. Here, we present a case of a consumptive coagulopathy due to a large venous malformation with a sustained correction of the fibrinogen depletion and associated bleeding tendency both with subcutaneous enoxaparin and with the oral factor Xa inhibitor rivaroxaban.

译文

:血管畸形中凝血的局部激活会导致消耗性凝血病,其特征为D-二聚体升高以及纤维蛋白原和血小板的消耗,最终导致出血倾向。通过减少凝血激活,用肝素进行的抗凝治疗能够限制这种止血功能失调和相关的出血情况。在这里,我们介绍了由于皮下依诺肝素和口服因子Xa抑制剂rivaroxaban引起的大静脉畸形,纤维蛋白原消耗的持续矫正以及相关的出血倾向而导致的消耗性凝血病。

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