The objective of the study is to investigate whether dopamine D2 receptor occupancy by risperidone and plasma levels over time can account for therapeutic efficacy and the latency period to response. Thirty-eight examinations with (123)I-IBZM single photon emission computed tomography were performed on 22 patients with schizophrenia, at diagnosis, 48 h after starting risperidone treatment and at a stable dose. Risperidone plasma levels were determined and psychopathologic evaluations (Brief Psychiatric Rating Scale, Positive and Negative Syndrome Scale) were carried out. No differences in the striatal/occipital (S/O) ratio or plasma levels were found between examinations at the 48-h time point and when a stable dose level had been established, so these parameters could not account for the latency period required for clinical response. D2 receptor occupancy at 48 h correlated positively with clinical improvement after 2 weeks of treatment. Therefore, if these results are confirmed, D2 receptor occupancy at the beginning of treatment with risperidone may be a predictor of subsequent clinical response.

译文

:该研究的目的是调查利培酮和血浆中多巴胺D2受体的占有率随时间的推移是否可以解释治疗效果和反应的潜伏期。对22例精神分裂症患者进行了38项(123)I-IBZM单光子发射计算机断层扫描检查,诊断时,开始使用利培酮治疗后48小时且剂量稳定。确定利培酮的血浆水平,并进行心理病理学评估(简明精神病评定量表,阳性和阴性综合征量表)。在48小时的时间点和建立稳定剂量水平后的两次检查之间,没有发现纹状体/枕骨(S / O)比或血浆水平存在差异,因此这些参数无法解释临床所需的潜伏期回复。治疗2周后,D2受体在48小时的占有率与临床改善呈正相关。因此,如果这些结果得到证实,利培酮治疗开始时D2受体的占有率可能是随后临床反应的预测指标。

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