The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers.

译文

:在热状态下的Z扫描(ZS)技术已用于测量低密度脂蛋白(LDL)的非线性光学响应。 ZS技术是在40名患有慢性牙周炎的LDL患者中,在进行牙周治疗的三个月,六个月和十二个月之前和之后进行的。还确定并比较了诸如探查深度,探查出血,白细胞总数和差异白细胞计数,脂质分布,细胞因子水平以及抗氧化LDL抗体等临床参数。在治疗之前,ZS实验结果表明这些患者的LDL颗粒已被大量修饰。仅在牙周治疗12个月后,获得的ZS结果显示出健康颗粒的行为特征。该结论也得到补充实验室分析的支持,该分析表明牙周治疗可诱导多种炎症标志物的全身性变化。

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