Thirty-three consecutive liver-transplant recipients were prospectively studied over a 37-mo period for evidence of cytomegalovirus infection. Sixteen (48%) episodes of cytomegalovirus infection were identified; 9 were primary infections and 7 were recurrent infections. Beginning with patient 8, gamma-globulin prophylaxis was routinely administered to most patients. Twelve potential risk factors for cytomegalovirus infection were evaluated and included pretransplant cytomegalovirus serological status of donor and recipient; recipient's age, sex, race, and liver disease; number and type of blood products transfused; type and intensity of immunosuppression; and occurrence of rejection. The Cox proportional hazards model identified positive donor cytomegalovirus serology as the single most important risk factor for subsequent development of cytomegalovirus infection, regardless of recipient cytomegalovirus serological status. In addition, use of gamma-globulin prophylaxis seemed to be protective against the occurrence of disseminated cytomegalovirus disease.

译文

:在37个月内对33例连续肝移植接受者进行了前瞻性研究,以发现巨细胞病毒感染的迹象。鉴定出十六例(48%)巨细胞病毒感染; 9例是原发性感染,7例是复发性感染。从患者8开始,常规对大多数患者进行了γ-球蛋白的预防。评价了十二种巨细胞病毒感染的潜在危险因素,包括供体和受体移植前巨细胞病毒的血清学状况;接受者的年龄,性别,种族和肝脏疾病;输血产品的数量和类型;免疫抑制的类型和强度;和拒绝的发生。 Cox比例风险模型将阳性供体巨细胞病毒血清学确定为随后发展成巨细胞病毒感染的唯一最重要的危险因素,而与受体巨细胞病毒血清学状况无关。另外,使用γ-球蛋白预防似乎可以预防弥漫性巨细胞病毒病的发生。

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