Cardiac troponin T (cTnT) and troponin I (cTnI) have been suggested as new, more specific markers of myocardial cellular damage. The objective of this study was to examine how the distributions of cTnI and cTnT were affected in postinfarction left ventricular remodeled (LVR) myocardium. At 2 months postinfarct in a porcine heart failure model, both Western blot and biochemical assay analyses were performed on left ventricular myocardium remote from the infarct zone in ligation animals (n = 8). Results were compared with data from the left ventricular myocardium from similar sized healthy (control) pigs (n = 7). Autoradiograms from Western blot analysis showed that the protein mass for cTnI and cTnT in LVR hearts decreased 80% (P < 0.001) and 40% (P < 0.02), respectively, when compared with nondiseased tissue. Similarly, the concentrations for cTnI and cTnT in LVR hearts decreased 42% (P < 0.05) and 70% (P < 0.001), respectively, compared with nondiseased normal tissue. The clinical assumption is that the appearance of cTnI and cTnT in the blood is proportional to chronic loss of cTnI and cTnT from injured myocardium associated with left ventricular remodeling.

译文

心肌肌钙蛋白T(cTnT)和肌钙蛋白I(cTnI)被认为是心肌细胞损伤的新的,更具体的标志物。这项研究的目的是检查梗死后左心室重构(LVR)心肌中cTnI和cTnT的分布如何受到影响。在猪心力衰竭模型中,梗死后2个月,在结扎动物中,对远离梗死区的左心室心肌进行了Western blot和生化分析(n = 8)。将结果与来自类似大小的健康(对照)猪(n = 7)的左心室心肌的数据进行比较。 Western blot分析的放射自显影照片显示,与未患病的组织相比,LVR心脏中cTnI和cTnT的蛋白质质量分别降低了80%(P <0.001)和40%(P <0.02)。同样,与未患病的正常组织相比,LVR心脏中cTnI和cTnT的浓度分别降低了42%(P <0.05)和70%(P <0.001)。临床假设是血液中cTnI和cTnT的出现与左心室重构相关的心肌损伤导致cTnI和cTnT的慢性丧失成比例。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录