In the present study we investigated the relation between cyclophosphamide and methotrexate toxicity and the presence of HLA- DR B1 alleles in rheumatoid arthritis patients. Seventy-eight such patients (67 women and 11 men) were observed for 12 months. Eighteen were treated with intravenous cyclophosphamide, 28 with oral methotrexate, and 32 with intramuscular gold salts. The prevalence of this shared motif was higher in the study population than in the healthy controls. However, detailed observations did not demonstrate a relation between particular genotype and drug intolerance. Based on the obtained findings we concluded that HLA-DR B1 typing cannot affect cyclophosphamide or methotrexate tolerance in rheumatoid arthritis patients. However, taking into account the relatively small number of patients expressing single genotype, further studies are recommended.

译文

:在本研究中,我们调查了类风湿关节炎患者中环磷酰胺和甲氨蝶呤毒性与HLA-DR B1等位基因之间的关系。观察了78名这样的患者(67名女性和11名男性),为期12个月。静脉注射环磷酰胺治疗18例,口服甲氨蝶呤治疗28例,肌内金盐治疗32例。在研究人群中,这种共有基序的患病率高于健康对照组。但是,详细的观察结果并未显示出特定基因型与药物耐受性之间的关系。根据获得的发现,我们得出结论,HLA-DR B1分型不能影响类风湿关节炎患者的环磷酰胺或甲氨蝶呤耐受性。但是,考虑到表达单一基因型的患者相对较少,建议进行进一步的研究。

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