OBJECTIVE:To summarise our experience with porcine urinary bladder matrix extracellular matrix (UBM) for the treatment of diabetic, venous, ischaemic or decubitus ulcerations and to outline appropriate protocol for its application. METHOD:A retrospective review was also conducted on all patients who received UBM (MatriStem; A Cell, Inc.) from January to December 201 I. Information regarding patient demographics, wound aetiology and location, as well as any prior treatments and follow-up data,were collected and reviewed from patients' medical records. RESULTS:Thirty-four patients were evaluated for this study. Mean patient age was 62.4 + 13.4 years (range 29-88 years) and 76% (n = 26) were male.The most common comorbidities were peripheral neuropathy (n = 20), diabetes mellitus type 2 (n = 19) and hypertension (n= 13). Mean wound duration prior to UBM application was 25.5 43.5 weeks, and mean time to healing following initial application was 9.8 9.3 weeks. All patients treated with UBM progressed to full healing. CONCLUSION:After addressing modifiable risk factors, our study suggests UBM is effective in the treatment of acute and recalcitrant diabetic or venous ulcerations when applied correctly with an appropriate dressing. DECLARATION OF INTEREST:There were no external sources of funding for this study.The authors have no conflicts of interest to declare.