OBJECTIVE:To summarise our experience with porcine urinary bladder matrix extracellular matrix (UBM) for the treatment of diabetic, venous, ischaemic or decubitus ulcerations and to outline appropriate protocol for its application. METHOD:A retrospective review was also conducted on all patients who received UBM (MatriStem; A Cell, Inc.) from January to December 201 I. Information regarding patient demographics, wound aetiology and location, as well as any prior treatments and follow-up data,were collected and reviewed from patients' medical records. RESULTS:Thirty-four patients were evaluated for this study. Mean patient age was 62.4 + 13.4 years (range 29-88 years) and 76% (n = 26) were male.The most common comorbidities were peripheral neuropathy (n = 20), diabetes mellitus type 2 (n = 19) and hypertension (n= 13). Mean wound duration prior to UBM application was 25.5 43.5 weeks, and mean time to healing following initial application was 9.8 9.3 weeks. All patients treated with UBM progressed to full healing. CONCLUSION:After addressing modifiable risk factors, our study suggests UBM is effective in the treatment of acute and recalcitrant diabetic or venous ulcerations when applied correctly with an appropriate dressing. DECLARATION OF INTEREST:There were no external sources of funding for this study.The authors have no conflicts of interest to declare.

译文

目的:总结我们在猪膀胱基质细胞外基质(UBM)上治疗糖尿病,静脉,缺血性或褥疮性溃疡的经验,并概述其应用的适当方案。
方法:还对所有201月份(201年1月至12月)接受UBM(MatriStem; A Cell,Inc.)的患者进行了回顾性研究。有关患者人口统计学,伤口病因和位置以及任何先前治疗和随访的信息从患者的病历中收集并审查数据。
结果:本研究评估了34例患者。平均患者年龄为62.4岁13.4岁(范围29-88岁),男性占76%(n = 26),最常见的合并症是周围神经病变(n = 20),2型糖尿病(n = 19)和高血压( n = 13)。 UBM施用前的平均伤口持续时间为25.5 43.5周,初次施用后的平均愈合时间为9.8 9.3周。所有接受UBM治疗的患者均已完全康复。
结论:在解决了可改变的危险因素后,我们的研究表明,正确使用适当的敷料,UBM可有效治疗急性和顽固性糖尿病或静脉溃疡。
利益声明:这项研究没有外部资金来源。作者没有利益冲突的声明。

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