PURPOSE:Also called acute febrile neutrophilic dermatosis, Sweet's syndrome is an inflammatory disorder with a prominent cutaneous expression. It is characterized by a variety of manifestations, clinical and histological findings. The objective of this study was to describe their clinical, pathological and therapeutic characteristics. METHODS:We report on a series of 47 patients who presented a Sweet's syndrome, collected in our institution in Tunis between 1997 and 2011. RESULTS:The patient population consisted of 11 men and 36 women. The mean age was 47 years with extreme ranging from 28 to 74 years. An associated disorder was observed in ten patients: inflammatory disease (three cases), inflammatory bowel disease (two cases), tuberculosis (three cases) and diabetes (three cases). One case of pregnancy was observed. Cutaneous lesions consisted of erythematous plaques or nodules. Lesions were located mainly on the upper or lower extremities. All biopsy specimens demonstrated a dermal infiltrate composed predominantly of neutrophils. Fibrinoid necrosis and intramural inflammation were observed in eight cases. CONCLUSION:The skin disorder can precede, follow, or appear concurrent with the diagnosis of an associated disease which requires careful surveillance.

译文

用途:又称急性发热性中性粒细胞性皮肤病,Sweet's综合征是一种具有明显皮肤表达的炎症性疾病。它的特征是多种表现,临床和组织学发现。这项研究的目的是描述其临床,病理和治疗特征。
方法:我们报道了1997年至2011年间在我们突尼斯机构中收集的47例患有Sweet's综合征的患者。
结果:该患者包括11名男性和36名女性。平均年龄为47岁,极端年龄为28至74岁。在十名患者中观察到相关疾病:炎性疾病(三例),炎性肠病(两例),结核病(三例)和糖尿病(三例)。观察到一例怀孕。皮肤病变由红斑或结节组成。病变主要位于上肢或下肢。所有活检标本均显示主要由中性粒细胞组成的皮肤浸润。八例观察到纤维蛋白样坏死和壁内炎症。
结论:皮肤疾病可以在相关疾病的诊断之前,之后或同时出现,需要仔细监测。

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